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Doxycycline-induced gastrointestinal injury
Kajsa Affolter1, Wade Samowitz2, Kathleen Boynton3
1Pathology, University of Utah School of Medicine and ARUP Laboratories, University of Utah Health Science Center, Huntsman Cancer Hospital, Salt Lake City, UT, USA, 84112.
Human Pathology
|March 14, 2017
Summary
Doxycycline can cause rare gastric injury, affecting small blood vessels in the stomach and duodenum. Stopping the medication helps improve symptoms and heal the damage.
Area of Science:
- Gastroenterology
- Drug-induced pathology
Background:
- Doxycycline is a widely prescribed antibiotic.
- Adverse gastrointestinal effects of doxycycline are not fully understood.
- Previous reports on doxycycline-induced gastric injury are limited.
Observation:
- This study investigated three cases of doxycycline-induced gastric injury.
- Histological review of gastric biopsies revealed small vessel injury with fibrinoid material.
- One patient also exhibited similar vascular changes in the duodenum.
Findings:
- Endoscopic examination showed fundic and pyloric erosions and ulcers in affected patients.
- Cessation of doxycycline treatment led to symptom improvement and endoscopic healing in one patient.
- The findings expand on previously described patterns of doxycycline-induced capillary degeneration.
Implications:
- Recognizing this specific drug-induced injury pattern is crucial for accurate diagnosis.
- Prompt identification and discontinuation of doxycycline can prevent further gastric damage.
- Understanding this adverse effect aids in better patient management and treatment strategies.
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