Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

1.1K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.1K
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

611
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
611
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

2.0K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.0K
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

55
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
55
Transgenic Organisms00:53

Transgenic Organisms

34.1K
Overview
34.1K
Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

98
Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
98

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Not all reference samples are equal in single-cell transcriptomics of human kidney tissue.

JCI insight·2026
Same author

HLA and non-HLA antibody profiling in the urine of kidney transplant recipients.

Expert review of proteomics·2025
Same author

Cellular and Spatial Drivers of Unresolved Injury and Functional Decline in the Human Kidney.

bioRxiv : the preprint server for biology·2025
Same author

Leukocyte immunoglobulin like receptor B3 (LILRB3) and allograft survival: can precision medicine target health disparities?

Kidney international·2025
Same author

Novel mechanism for tubular injury in nephropathic cystinosis.

eLife·2025
Same author

Cytotoxic KLRG1+ IL-7R- effector CD8+ T cells distinguish kidney transplant recipients controlling cytomegalovirus reactivation.

Frontiers in immunology·2025
Same journal

Genetic origins and constraints of evolutionary innovation.

Nature reviews. Genetics·2026
Same journal

Single-cell four-omics with CHARM.

Nature reviews. Genetics·2026
Same journal

Molecular integration of seasonal temperature signals in flowering time control.

Nature reviews. Genetics·2026
Same journal

RBPscan measures protein-RNA interactions in living cells.

Nature reviews. Genetics·2026
Same journal

Revisiting retinal and macular degeneration in the genomics era.

Nature reviews. Genetics·2026
Same journal

How evolution builds three morphs from one genome.

Nature reviews. Genetics·2026
See all related articles

Related Experiment Video

Updated: Mar 6, 2026

Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm
08:12

Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm

Published on: December 22, 2016

12.5K

Transplant genetics and genomics.

Joshua Y C Yang1, Minnie M Sarwal1

  • 1Division of Transplant Surgery, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA.

Nature Reviews. Genetics
|March 14, 2017
PubMed
Summary
This summary is machine-generated.

Genetic and genomic studies advance transplant science, revealing donor-recipient interactions for tolerance or rejection. This genetic analysis enables personalized medicine for risk stratification and tailored immunosuppression.

More Related Videos

Orthotopic Hind Limb Transplantation in the Mouse
07:15

Orthotopic Hind Limb Transplantation in the Mouse

Published on: February 12, 2016

12.4K
Using Quantitative Real-time PCR to Determine Donor Cell Engraftment in a Competitive Murine Bone Marrow Transplantation Model
10:11

Using Quantitative Real-time PCR to Determine Donor Cell Engraftment in a Competitive Murine Bone Marrow Transplantation Model

Published on: March 7, 2013

15.9K

Related Experiment Videos

Last Updated: Mar 6, 2026

Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm
08:12

Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm

Published on: December 22, 2016

12.5K
Orthotopic Hind Limb Transplantation in the Mouse
07:15

Orthotopic Hind Limb Transplantation in the Mouse

Published on: February 12, 2016

12.4K
Using Quantitative Real-time PCR to Determine Donor Cell Engraftment in a Competitive Murine Bone Marrow Transplantation Model
10:11

Using Quantitative Real-time PCR to Determine Donor Cell Engraftment in a Competitive Murine Bone Marrow Transplantation Model

Published on: March 7, 2013

15.9K

Area of Science:

  • Transplantation immunology
  • Genomics
  • Personalized medicine

Background:

  • The discovery of the major histocompatibility complex has been pivotal in advancing transplantation science.
  • Genetic and genomic studies have significantly improved our understanding of transplant tolerance and rejection.
  • Candidate-gene approaches and genome-wide association studies (GWAS) offer deeper insights into donor-recipient interactions.

Purpose of the Study:

  • To highlight the role of genetic and genomic studies in advancing transplantation.
  • To explore how genetic analysis can drive personalized medicine in transplantation.
  • To identify genetic variants associated with transplant outcomes and complications.

Main Methods:

  • Review of genetic and genomic studies in transplantation.
  • Analysis of candidate-gene approaches and GWAS.
  • Linking genetic data with demographic and clinical outcomes.

Main Results:

  • Genetic studies have elucidated complex donor-recipient interactions influencing transplant outcomes.
  • GWAS have provided a deeper understanding of the genetic basis of transplant tolerance and rejection.
  • Identification of genetic variants associated with immune-mediated complications and post-transplant diseases.

Conclusions:

  • Genetic analysis in transplantation is crucial for understanding immune responses.
  • Linking genetic data with clinical outcomes enables personalized risk stratification.
  • Genomic insights pave the way for individualized immunosuppression strategies and improved patient care.