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Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention
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Magnetizable stent-grafts enable endothelial cell capture.

Brandon J Tefft1, Susheil Uthamaraj2, J Jonathan Harburn3

  • 1Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN., USA.

Journal of Magnetism and Magnetic Materials
|March 14, 2017
PubMed
Summary

Magnetized stent-grafts coated with nanofibers successfully captured endothelial cells using superparamagnetic iron oxide nanoparticles (SPION). This magnetic cell targeting shows promise for improved vascular stent-graft healing and performance.

Keywords:
BOECSPIONelectrospinningendothelializationpolyurethane

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cardiovascular Research

Background:

  • Magnetic forces guide magnetically-labeled agents for therapeutic applications.
  • Superparamagnetic iron oxide nanoparticles (SPION) label endothelial cells for magnetic capture.
  • Previous studies captured SPION-labeled cells on magnetic stents in porcine models.

Purpose of the Study:

  • To fabricate and evaluate prototype stent-grafts coated with electrospun polyurethane nanofibers.
  • To assess the ability of magnetized stent-grafts to capture SPION-labeled endothelial cells.
  • To evaluate the early performance of these stent-grafts in a porcine coronary model.

Main Methods:

  • Coating magnetizable 2205 duplex stainless steel stents with electrospun polyurethane nanofibers.
  • Fabricating prototype magnetized stent-grafts.
  • Capturing SPION-labeled endothelial cells onto stent-grafts using an external magnetic field.
  • Implanting stent-grafts in porcine coronary arteries (n=13) and evaluating cell capture and tissue response at 7 days.

Main Results:

  • Magnetized stent-grafts successfully captured SPION-labeled endothelial cells to regions adjacent to and between stent struts.
  • Non-magnetized control stent-grafts did not capture cells.
  • Implanted devices remained patent with thin, uniform neointima, showing no thrombosis or inflammation at 7 days.

Conclusions:

  • Prototype magnetized stent-grafts demonstrate feasibility for targeted endothelial cell capture.
  • This approach facilitates early arterial healing and may improve long-term stent-graft performance.
  • Further refinements are needed for uniform cell capture and complete endothelialization.