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Updated: Mar 6, 2026

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Published on: November 27, 2019
Primary Hepatic Amyloidosis Presenting as Acute-on-Chronic Liver Failure
Madhumita Premkumar1, Devaraja Rangegowda1, Tanmay Vyas1
1Department of Hepatology, Institute of Liver and Biliary Sciences, Vasant Kunj, New Delhi, India.
Abstract:
Systemic amyloidosis of amyloid light chain associated protein (AL), also called primary amyloidosis, frequently involves the liver, but rarely causes clinically apparent liver disease. The more common presentation is with acute renal failure. Hepatomegaly and mild elevation of alkaline phosphatase are the most common clinical and biochemical findings, respectively. We report a case of systemic amyloidosis of AL that clinically presented as acute-on-chronic liver failure and resulted in a fatal clinical course in a 56-year-old man.
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Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
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