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Related Experiment Video

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Measuring and Modeling Contractile Drying in Human Stratum Corneum
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Measuring and Modeling Contractile Drying in Human Stratum Corneum.

Xue Liu1, Guy K German2

  • 1Department of Biomedical Engineering, Binghamton University.

Journal of Visualized Experiments : Jove
|March 14, 2017
PubMed
Summary

This study introduces a new method to measure how skin

Area of Science:

  • Biophysics
  • Materials Science
  • Dermatology

Background:

  • The stratum corneum (SC), the outermost skin layer, is vulnerable to environmental factors like moisture and cleansing agents.
  • Changes in SC water content can affect its stiffness, leading to drying stresses and potential mechanical rupture.
  • Understanding SC mechanical properties is crucial for assessing skin barrier function and the efficacy of cosmetic products.

Purpose of the Study:

  • To develop and validate a high-throughput method for quantifying dynamic changes in the mechanical properties of the stratum corneum during drying.
  • To assess the impact of cosmetic cleanser and moisturizer treatments on SC drying behavior and mechanical properties.

Main Methods:

  • A novel technique measures dynamic, spatially resolved in-plane drying displacements of circular SC samples on an elastomer substrate.

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  • Azimuthal averaging of radial displacements during drying.
  • Fitting displacement data to a linear elastic contractility model to extract mechanical parameters.

    • Main Results:

    • The developed method successfully quantifies dynamic changes in SC mechanical properties upon drying.
    • The technique allows for the assessment of how cosmetic treatments alter SC drying behavior and elasticity.
    • Dynamic changes in drying stress and SC elastic modulus can be accurately extracted.

    Conclusions:

    • A high-throughput method for analyzing SC mechanical properties during drying has been established.
    • This technique provides a valuable tool for evaluating the effects of skincare products on skin barrier function.
    • The study offers insights into the mechanical responses of the stratum corneum to environmental and treatment-induced changes.