Related Experiment Video

Updated: Mar 6, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

8.0K

Circulating miRNA29 family expression levels in patients with essential hypertension as potential markers for left

Yuqing Huang1, Songtao Tang2, Cheng Huang1

  • 1a Department of Cardiology , Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Disease, Guangdong General Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology , Guangzhou , China.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|March 14, 2017
PubMed

Insights

Elevated levels of circulating microRNAs (miRs) miR-29a, miR-29b, and miR-29c were observed in patients with essential hypertension. These miRs show potential as non-invasive biomarkers for hypertension-related target-organ damage.

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Biomarker Discovery

Background:

  • Hypertension poses a significant risk for cardiovascular diseases.
  • Target-organ damage (TOD) in hypertension lacks specific diagnostic biomarkers.
  • MicroRNAs (miRs) are increasingly recognized for their role in cardiovascular pathogenesis.

Purpose of the Study:

  • To identify and validate circulating miRs as novel biomarkers for TOD in essential hypertension.
  • To assess the expression levels of miR-29a, miR-29b, and miR-29c in hypertensive patients.
  • To correlate miR expression with blood pressure and echocardiographic parameters.

Main Methods:

  • Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) to measure miR-29a, miR-29b, and miR-29c expression.
  • Analysis of 54 untreated essential hypertension patients and 30 healthy controls.
  • Echocardiography and ambulatory blood pressure monitoring to assess TOD and hypertension severity.

Main Results:

  • Hypertensive patients exhibited significantly higher expression of miR-29a, miR-29b, and miR-29c compared to healthy individuals.
  • Elevated miR-29 family expression was also noted in hypertensive patients with left ventricular hypertrophy (LVH).
  • Significant positive correlations were found between miR-29 levels and various blood pressure parameters (SBP, DBP, PP) and left ventricular mass index (LVMI).

Conclusions:

  • The miR-29 family (miR-29a, miR-29b, miR-29c) shows promise as potential non-invasive biomarkers.
  • These circulating miRs may aid in diagnosing hypertension and its associated target-organ damage.
  • Further research is warranted to fully establish their clinical utility.
Abstract

Keywords:
Essential hypertensionleft ventricular hypertrophymiR-29amiR-29bmiR-29c

More Related Videos

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization08:22

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

8.6K
Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

8.7K

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
668
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
786
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
689
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
588