Bone Healing Evaluation in Critical-Size Defects Treated With Xenogenous Bone Plus Porcine Collagen
Related Experiment Video
Updated: Mar 6, 2026
Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model
Published on: August 13, 2017
Juceléia Maciel1, Gustavo Antonio Correa Momesso, Gabriel Ramalho-Ferreira
1*PhD Student, Department of Surgery and Integrated Clinic, Araçatuba Dental School, University Estadual Paulista (UNESP), Araçatuba, São Paulo, Brazil. †MSc Student, Department of Surgery and Integrated Clinic, Araçatuba Dental School, University Estadual Paulista (UNESP), Araçatuba, São Paulo, Brazil. ‡Assistant Professor, Department of Oral Pathology, Faculty Adamantinenses Integradas, Adamantina, Sao Paulo, Brazil. §Full Professor, Department of Surgery and Integrated Clinic, Araçatuba Dental School, University Estadual Paulista (UNESP), Araçatuba, São Paulo, Brazil; Department of Oral Pathology, Faculty Adamantinenses Integradas, Adamantina, Sao Paulo, Brazil. ¶Assistant Professor, Department of Surgery and Integrated Clinic, Araçatuba Dental School, University Estadual Paulista (UNESP), Araçatuba, São Paulo, Brazil.
Purpose:
This study aimed to evaluate the osteoconductive features of Bio-Oss Collagen in large critical-size defects (8 mm).
Materials And Methods:
Thirty-six adult Wistar Albinus male adult rats were carried out a critical-size defect with a trephine bur of 8 mm in the calvaria. Groups were divided depending on the filling biomaterial as follows: group BO: Bio-Oss (n = 18); group BOC: Bio-Oss Collagen (n = 18). After 7, 30, and 60 days, 6 rats of each group were euthanized with anesthetic overdose. Specimens were laboratory processed for histomorphometric analysis. Histomorphometric data were statistically analyzed by analysis of variance and post-Tukey test (P < 0.05).
Results:
Statistical differences were found in new bone formation just in the intragroup comparison among periods after 7 and 60 postoperative days, indicating more new bone formation after 60 days (Tukey test, P = 0.029).
Conclusion:
Under the limitation of this research, it could be concluded that Bio-Oss and Bio-Oss Collagen in this experimental model did not show osteoconductive features.
More Related Videos
06:38Establishment of a Segmental Femoral Critical-size Defect Model in Mice Stabilized by Plate Osteosynthesis
Published on: October 12, 2016
08:20A Reliable and Reproducible Critical-Sized Segmental Femoral Defect Model in Rats Stabilized with a Custom External Fixator
Published on: March 24, 2019