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Updated: Mar 6, 2026

Mapping the Cellular Distribution of an Optogenetic Protein Using a Light-Stimulation Grid
Published on: January 26, 2024
How to control cyclic nucleotide signaling by light
Vera Jansen1, Jan F Jikeli1, Dagmar Wachten2
1Center of Advanced European Studies and Research (caesar), Minerva Max Planck Research Group, Molecular Physiology, Bonn, Germany.
Abstract:
Optogenetics allows to non-invasively manipulate cellular functions with spatio-temporal precision by combining genetic engineering with the control of protein function by light. Since the discovery of channelrhodopsin has pioneered the field, the optogenetic toolkit has been ever expanding and allows now not only to control neuronal activity by light, but rather a multitude of other cellular functions. One important application that has been established in recent years is the light-dependent control of second messenger signaling. The optogenetic toolkit now allows to control cyclic nucleotide-dependent signaling by light in vitro and in vivo.
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