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Cdk5 links with DNA damage response and cancer

Wan Liu1, Jun Li1, Yu-Shu Song1

  • 1Department of Breast Surgery, The Second Affiliated Hospital of Dalian Medical University, Zhongshan Road 467, Dalian, 116023, China.

Molecular Cancer
|March 15, 2017
PubMed

Insights

Cyclin dependent kinase 5 (Cdk5) is involved in cancer and DNA damage response. Inhibiting Cdk5 shows anti-cancer effects and enhances chemotherapy efficacy.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Cyclin dependent kinase 5 (Cdk5) was historically considered neuron-specific.
  • Emerging evidence implicates Cdk5 in non-neuronal cellular processes and cancer.
  • Cdk5 dysregulation is observed in various cancer types.

Purpose of the Study:

  • To elucidate the regulatory mechanisms of Cdk5.
  • To investigate the controversial roles of Cdk5 in apoptosis.
  • To focus on the connection between Cdk5, DNA damage response (DDR), and cancer.

Main Methods:

  • Literature review and synthesis of existing research on Cdk5.
  • Analysis of Cdk5's role in non-neuronal cells and cancer.
  • Examination of Cdk5's involvement in DNA damage response pathways.

Main Results:

  • Cdk5 exhibits diverse biological and pathological functions beyond neuronal cells.
  • Cdk5 inhibition or knockdown demonstrates anti-cancer properties.
  • Cdk5 activity can potentiate the effectiveness of chemotherapeutic agents.

Conclusions:

  • Cdk5 plays a significant role in cancer development and progression.
  • Understanding Cdk5's link to DNA damage response is crucial for cancer therapy.
  • Targeting Cdk5 presents a potential therapeutic strategy for cancer treatment.
Keywords:
ApoptosisCancerCyclin dependent kinase 5DNA damage responseTargeted cancer therapy

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