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Updated: Mar 6, 2026

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

Published on: June 16, 2017

Methylation patterns in marginal zone lymphoma.

Alberto J Arribas¹, Francesco Bertoni²

¹Lymphoma & Genomics Research Program, Institute of Oncology Research (IOR), Bellinzona, Switzerland.

Best Practice & Research. Clinical Haematology

|March 15, 2017

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DNA methylation significantly impacts gene expression in marginal zone lymphomas. Understanding these methylation changes is crucial for disease pathogenesis, prognosis, and developing targeted therapies for these lymphomas.

Area of Science:

Epigenetics
Oncology
Molecular Biology

Background:

DNA methylation is a key epigenetic mechanism regulating gene expression and transcription.
Aberrant DNA methylation patterns are implicated in various diseases, including lymphomas.
Marginal zone lymphomas (MZLs) encompass MALT lymphoma, splenic marginal zone lymphoma, and nodal marginal zone lymphoma, each with distinct characteristics.

Purpose of the Study:

To review and summarize current knowledge on DNA methylation in MALT lymphoma, splenic marginal zone lymphoma, and nodal marginal zone lymphoma.
To elucidate the role of DNA methylation in the pathogenesis and progression of MZLs.
To identify potential therapeutic strategies targeting DNA methylation in MZLs.

Main Methods:

Literature review of studies investigating DNA methylation in MZLs.

Keywords:

CIMP Decitabine Lymphoma MALT Marginal zone Methylation

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Analysis of existing genome-wide and targeted methylation studies.

Synthesis of findings regarding methylation patterns and their functional consequences.

Main Results:

DNA methylation plays a critical role in MZLs, influencing both tumor suppressor gene inactivation and oncogene activation.
Specific methylation alterations contribute to tumor cell survival and proliferation in MZLs.
Despite variations in study designs, a consistent role for DNA methylation across different MZL subtypes is evident.

Conclusions:

DNA methylation is a significant factor in the biology of marginal zone lymphomas.
Targeting the DNA methylation machinery presents a promising therapeutic avenue for MZLs.
Further research into methylation patterns can improve prognostic markers and treatment strategies.