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Related Experiment Video

Updated: Mar 6, 2026

Analysis of Shear Flow-induced Migration of Murine Marginal Zone B Cells In Vitro
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Bacteria associated with marginal zone lymphomas.

Maurilio Ponzoni1, Andrés J M Ferreri2

  • 1Ateneo Vita Salute, Pathology Unit and Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy.

Best Practice & Research. Clinical Haematology
|March 15, 2017
PubMed
Summary
This summary is machine-generated.

Certain bacteria are linked to marginal zone lymphomas, impacting treatment and understanding. This review explores these microbial associations, their clinical significance, and future research directions.

Keywords:
AchromobacterBacteriaBorreliaCampylobacterChlamydiaHaemophilusHelicobacterInfectionLymphoma

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Area of Science:

  • Microbiology
  • Oncology
  • Immunology

Background:

  • Marginal zone lymphomas (MZLs) encompass nodal, splenic, and extranodal types.
  • Chronic infections are increasingly associated with various lymphomas, influencing clinical and molecular aspects.
  • Established links include Helicobacter pylori with gastric MALT lymphoma, Chlamydia psittaci with ocular adnexal MALT lymphoma, and Borrelia burgdorferi with cutaneous MALT lymphoma.

Purpose of the Study:

  • To review the association between specific bacteria and marginal zone lymphomas.
  • To discuss the clinical, molecular, and biological implications of these lymphoma-microbial associations.
  • To explore therapeutic strategies and future research avenues for these conditions.

Main Methods:

  • Literature review of studies investigating bacterial involvement in MZLs.
  • Analysis of clinical data, molecular mechanisms, and biological interactions.
  • Synthesis of information on therapeutic outcomes and future research perspectives.

Main Results:

  • Several bacteria, including Helicobacter pylori, Chlamydia psittaci, Borrelia burgdorferi, Campylobacter jejuni, Achromobacter xylosoxidans, and Haemophilus influenzae, have been linked to specific MZL subtypes.
  • These associations have significant clinical, molecular, and biological implications.
  • Understanding these links is crucial for developing targeted therapies.

Conclusions:

  • Bacterial infections play a significant role in the pathogenesis and progression of certain marginal zone lymphomas.
  • Further research is needed to elucidate the precise mechanisms and to develop effective, targeted treatment strategies.
  • Microbial associations offer potential avenues for novel therapeutic interventions in MZL management.