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Three-Dimensional Bioprinting Strategies for Tissue Engineering.

Yu Shrike Zhang^1,2,3, Rahmi Oklu^1,4, Mehmet Remzi Dokmeci^1,2,3

¹Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts 02139.

Cold Spring Harbor Perspectives in Medicine

|March 15, 2017

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3D bioprinting offers precise control over spatial architecture, overcoming limitations in fabricating complex functional tissues and extracellular matrices for tissue engineering applications.

Area of Science:

Biomaterials Science
Tissue Engineering
Biotechnology

Background:

Traditional methods for fabricating biomimetic extracellular matrices struggle with precise spatial architecture control.
This limitation hinders the engineering of complex, functional tissues.

Purpose of the Study:

To review the application of 3D bioprinting in tissue engineering.
To discuss strategies for printing functional tissue constructs.
To highlight the advantages of nozzle-based bioprinting techniques.

Main Methods:

Review of current literature on 3D bioprinting strategies for tissue engineering.
Focus on nozzle-based bioprinting techniques and their benefits.
Analysis of existing technologies and future challenges.

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Main Results:

3D bioprinting provides unprecedented freedom and versatility in depositing biological materials and cells.
Precision engineering of functional tissues is achievable through controlled deposition.
Nozzle-based techniques offer specific advantages in bioprinting complex constructs.

Conclusions:

3D bioprinting is a promising solution for overcoming spatial control challenges in tissue engineering.
Further development is needed to address current technological limitations.
Future research should focus on advancing bioprinting capabilities for complex tissue fabrication.