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Related Experiment Video

Updated: Mar 6, 2026

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
07:21

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

3.7K

Biochemical changes in the injured brain.

Seelora Sahu1, Deb Sanjay Nag1, Amlan Swain1

  • 1Seelora Sahu, Deb Sanjay Nag, Amlan Swain, Devi Prasad Samaddar, Department of Anaesthesia and Critical Care, Tata Main Hospital, Jamshedpur 831001, India.

World Journal of Biological Chemistry
|March 15, 2017
PubMed
Summary

Biochemical markers aid in managing brain injuries like TBI and stroke. These markers help assess injury severity and predict patient outcomes, improving clinical decision-making.

Keywords:
BiomarkersBrain injuriesBrain ischemiaEpilepsySubarachnoid hemorrhage

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Clinical Neurology

Background:

  • Brain metabolism is energy-intensive, and injuries disrupt crucial homeostatic and electrophysiological processes.
  • Biochemical markers of brain injury are emerging tools for neuro-clinicians.
  • These markers are vital for managing conditions like traumatic brain injury, stroke, and intracranial lesions.

Discussion:

  • Biochemical markers assist in evaluating the severity of brain injury.
  • They are increasingly used to predict the prognostic course of neurological conditions.
  • Specific markers like S-100 protein and neuron-specific enolase show prognostic and clinical value.

Key Insights:

  • Early biomarkers (S-100, GFAP, UCH-L1) aid initial clinical decisions in acute neuronal crises.
  • Other markers are valuable for predicting long-term complications and prognosis.
  • Cerebral microdialysis monitors brain metabolites (glucose, lactate, glutamate).

Outlook:

  • Small non-coding RNAs show promise as future brain injury biomarkers.
  • Continued research into biochemical markers will refine diagnosis and prognosis.
  • Advanced monitoring techniques like cerebral microdialysis offer new insights into brain metabolism during injury.