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Effect of Systemic Antioxidant Allopurinol Therapy on Skin Flap Survival
Mehdi Rasti Ardakani1, Ahmed Al-Dam2, Ashkan Rashad2
1Department of Plastic Surgery, Isfahan University of Medical Sciences, Isfahan, Iran.
Background:
It has been reported that systemic administration of allopurinol improves cell survival. This study was aimed to evaluate effects of allopurinol on skin flaps in dogs.
Methods:
Twenty dogs underwent one skin flap surgery with a 2-week interval. The first procedure was performed according to the standard protocols. The second phase was started by a 1-week pretreatment with allopurinol. Length of the necrotic zone was measured and recorded daily. At each phase, flaps were removed and sent for histopathological study after 1 week observation.
Results:
Mean length of the necrotic zone in allopurinol treated skin flaps has been significantly less than normal flaps over all 7 days of observation (p<0.0001). Histopathology study showed less inflammation and more normal tissue structure in the allopurinol treated skin flaps.
Conclusion:
It was demonstrated that systemic administration of allopurinol significantly improved skin flap survival.
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