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Anomalous binding of DPDPE as a result of batch variability
L Taylor1, A Mansour, S J Watson
1Mental Health Research Institute, University of Michigan Medical Center, Ann Arbor 48109-0720.
Abstract:
The binding of the delta selective agonist [3H]DPDPE to diencephalic rat brain tissue was examined. Although most material examined gave rise to a single receptor model, one commercial preparation (Amersham, batch 8) suggested a two receptor model. Purification by HPLC removed a minor component and restored a single receptor model to the major component.