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Molecular mechanisms of ligand binding to opioid receptors: selective inhibition by ethanol?
R S Rapaka1, H N Bhargava, V Renugopalakrishnan
1Division of Preclinical Research, National Institute on Drug Abuse, Rockville, MD 20857.
NIDA Research Monograph
|January 1, 1986
Abstract:
Effects of varying concentrations of ethanol on the conformations of DAGO, a mu-specific opioid ligand were monitored by FT-IR spectroscopy. The binding of 3H-labeled DAGO (mu-agonist) and DSLET (delta-agonist) to opioid receptors in the presence of varying concentrations of alcohol was also determined. The results indicate that the conformational features of the ligands are altered and conformational factors may play a role in ligand-receptor interaction.