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Opiate receptor binding and behavioral effects of morphine in RHA/Verh and RLA/Verh rats
D Lazega1, P Driscoll, H R Frischknecht
1Inst. of Pharmacology, Univ. of Zurich, Switzerland.
NIDA Research Monograph
|January 1, 1986
Abstract:
Large baseline differences were found in open field activity and rearing behavior between 2 psychogenetically selected rat lines, as well as differences in the effects of peripherally administered morphine (2,4 and 10 mg/kg) on those behaviors and on body temperature. The 2 lines also showed different capacities of tritiated DAGO binding to preparations of striatal membranes.