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Once-daily tablet formulation and in vitro release evaluation of cefpodoxime using hydroxypropyl methylcellulose: A

Hamid A Merchant1, Harris M Shoaib2, Jaweria Tazeen1

  • 1Faculty of Pharmacy, University Road, 75270, Karachi, Pakistan.

AAPS Pharmscitech
|March 15, 2017
PubMed

Insights

Developing a once-daily sustained-release tablet of cefpodoxime proxetil using HPMC enhances patient compliance and bacterial killing rates. This formulation effectively controls drug release for 24 hours, offering a promising alternative for improved therapeutic outcomes.

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Pharmacokinetics

Background:

  • Patient compliance with antibiotic regimens is often limited by frequent dosing schedules.
  • Cefpodoxime proxetil is an effective antibiotic, but its conventional dosing may impact adherence.
  • Sustained-release formulations offer potential for improved patient compliance and therapeutic efficacy.

Purpose of the Study:

  • To develop and characterize a once-daily sustained-release tablet formulation of cefpodoxime proxetil.
  • To evaluate the in vitro drug release profile and kinetics of the developed formulation.
  • To assess the suitability of the formulation for improved patient compliance.

Main Methods:

  • Formulation of cefpodoxime proxetil sustained-release tablets utilizing a hydrophilic HPMC matrix.
  • Evaluation of pharmacotechnical properties including assay and tablet characteristics.
  • In vitro dissolution studies conducted over 24 hours.
  • Analysis of drug release kinetics using Higuchi, Korsmeyer-Peppas, and Hixson-Crowell models.

Main Results:

  • The HPMC matrix effectively controlled cefpodoxime proxetil release for 24 hours, achieving a sustained-release profile.
  • The formulation exhibited acceptable pharmacotechnical properties and met assay requirements.
  • In vitro dissolution data closely matched theoretical release profiles, with drug release best described by Higuchi's equation (r²=0.9734).
  • Korsmeyer-Pappas analysis indicated an anomalous diffusion mechanism (n=0.57), suggesting combined diffusion and erosion control.

Conclusions:

  • A once-daily sustained-release tablet of cefpodoxime proxetil can be effectively developed using an HPMC matrix.
  • The formulation demonstrates favorable in vitro release characteristics, supporting improved patient compliance and potentially enhanced therapeutic outcomes.
  • The drug release mechanism involves a combination of diffusion and matrix erosion, providing a controlled release profile over 24 hours.
Keywords:
Cefpo SRCefpodoxime proxetilhydrophilic matrix tabletshydroxypropyl methylcellulose (HPMC)in vitro sustained drug releaseonce-daily tablet

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