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Local and average gloss from flat-faced sodium chloride tablets.

Mikko Juuti1, Bert van Veen2, Kai-Erik Peiponen3

  • 1Department of Physics, University of Joensuu, PO Box 111, FI-80101, Joensuu, Finland. mikko.juuti@joensuu.fi.

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Gloss variation measurement using a diffractive optical element-based gloss-meter (DOG) effectively detects surface structure changes in sodium chloride tablets, revealing insights into particle behavior during compression.

Keywords:
glosssodium chloridesurface structuretablet

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Surface Science

Background:

  • Tablet surface structure is critical for drug dissolution and stability.
  • Conventional methods for surface analysis can be time-consuming or provide limited information.
  • Understanding surface changes during tablet manufacturing is essential for quality control.

Purpose of the Study:

  • To investigate the utility of a novel diffractive optical element-based gloss-meter (DOG) for detecting local gloss and surface structure changes in sodium chloride tablets.
  • To correlate gloss variations with surface roughness and microstructural changes.
  • To assess the impact of compression force on tablet surface characteristics.

Main Methods:

  • Sodium chloride tablets were analyzed using a diffractive optical element-based gloss-meter (DOG) to create 2D gloss maps.
  • Surface roughness was measured using diamond stylus profilometry.
  • Scanning electron microscopy (SEM) was employed for high-resolution imaging of tablet surfaces.
  • Gloss variation data was compared with profilometry and SEM results.

Main Results:

  • Tablet surface roughness decreased with increasing compression force.
  • Contrary to expectations, average gloss values decreased with increasing compression force.
  • SEM images revealed particle fragmentation, deformation, and crack formation, correlating with gloss loss.
  • The DOG successfully detected local gloss variations indicative of these microstructural changes.

Conclusions:

  • Local gloss variation, as measured by DOG, is a sensitive indicator of surface structure changes in sodium chloride tablets.
  • The observed decrease in gloss with compression force is attributed to particle fragmentation and deformation.
  • DOG offers a valuable, non-destructive method for characterizing tablet surface topography and manufacturing-induced changes.