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Brain functional connectivity in lung cancer population: an exploratory study.

M Simó1,2, X Rifà-Ros1,3, L Vaquero1

  • 1Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, 08907, Barcelona, Spain.

Brain Imaging and Behavior
|March 15, 2017
PubMed
Summary
This summary is machine-generated.

Lung cancer and chemotherapy disrupt brain connectivity. Resting State Networks (RSNs) show decreased Default Mode Network (DMN) connectivity and increased connectivity in other networks, potentially as a compensatory mechanism.

Keywords:
ChemotherapyDefault mode networkFunctional connectivityLung cancerResting-state functional magnetic resonance imaging

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Area of Science:

  • Neuroscience
  • Oncology
  • Medical Imaging

Background:

  • Cancer and its treatments, like chemotherapy, can impact cognitive function.
  • Understanding the neural underpinnings of these cognitive changes is crucial for patient care.

Purpose of the Study:

  • To investigate functional connectivity differences in Resting State Networks (RSNs) in lung cancer patients undergoing chemotherapy.
  • To identify specific RSNs affected by cancer and chemotherapy using Independent Component Analysis (ICA).

Main Methods:

  • Utilized ICA to analyze functional connectivity in three groups: lung cancer patients post-chemotherapy (C+), pre-chemotherapy (C-), and healthy controls (HC).
  • Employed multivariate pattern analysis (MVPA) to classify groups based on functional connectivity profiles.

Main Results:

  • Significant differences in functional connectivity were observed in the Default Mode Network (DMN), Anterior Temporal Networks, and Cerebellum Network.
  • DMN connectivity was decreased in lung cancer patients compared to controls, while other identified RSNs showed increased connectivity.
  • Chemotherapy further altered connectivity patterns, with C+ patients exhibiting distinct changes compared to C- patients.

Conclusions:

  • Disrupted functional connectivity in lung cancer patients involves both decreased DMN connectivity and increased connectivity in other RSNs.
  • These connectivity alterations may underlie chemotherapy-induced cognitive deficits and suggest potential compensatory mechanisms.
  • Functional connectivity analysis offers a valuable tool for understanding the neurological effects of cancer and its treatment.