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John W Blunt1, Brent R Copp2, Robert A Keyzers3

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This review details marine natural products (MNPs) discovered in 2015, focusing on new compounds from diverse marine organisms and their biological activities. It highlights advancements in MNP research, including biosynthesis and synthesis studies.

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Area of Science:

  • Marine Natural Products Chemistry
  • Marine Pharmacology
  • Organic Chemistry

Background:

  • Marine natural products (MNPs) represent a rich source of novel chemical structures with diverse biological activities.
  • Previous reviews have documented the ongoing discovery and characterization of MNPs from various marine sources.

Purpose of the Study:

  • To comprehensively review the literature on marine natural products published in 2015.
  • To highlight newly discovered MNPs, their source organisms, and associated biological activities.
  • To include relevant biosynthetic studies, first syntheses, and structure revisions.

Main Methods:

  • Literature search for marine natural products published in 2015.
  • Categorization of compounds based on source organisms (microorganisms, algae, invertebrates, plants).
  • Analysis of reported biological activities, biosynthetic pathways, and synthetic studies.

Main Results:

  • 1220 citations were reviewed, with 792 focusing on January-December 2015.
  • 1340 new compounds were reported in 429 papers.
  • Data included source organisms, country of origin, and biological activities for new MNPs.

Conclusions:

  • The year 2015 was highly productive for marine natural product discovery.
  • Continued exploration of marine biodiversity yields novel compounds with potential therapeutic applications.
  • Advances in synthetic chemistry facilitate structural elucidation and development of MNPs.