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[Prognostic Significance of Erythropoietin in Patients With Acute Coronary Syndrome]

M V Menzorov1, A M Shutov1, N V Larionova1

  • 1Ulyanovsk State University, Ulyanovsk, Russia.

Kardiologiia
|March 15, 2017
PubMed

Insights

Elevated erythropoietin (EPO) levels in acute coronary syndrome (ACS) patients predict in-hospital mortality and acute kidney injury (AKI). Higher EPO serum levels were observed in non-survivors.

Area of Science:

  • Cardiology
  • Nephrology
  • Biomarkers

Background:

  • Acute coronary syndrome (ACS) is a critical cardiovascular condition.
  • Erythropoietin (EPO) is a hormone primarily involved in red blood cell production.
  • The prognostic role of EPO in ACS patients requires further investigation.

Purpose of the Study:

  • To investigate the prognostic significance of serum erythropoietin (EPO) levels in patients diagnosed with acute coronary syndrome (ACS).
  • To determine if EPO levels can predict in-hospital mortality and acute kidney injury (AKI) in ACS patients.

Main Methods:

  • Serum EPO levels were measured at hospital admission in 84 ACS patients.
  • Patients included ST-elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction, and unstable angina (UA).
  • Coronary angiography during hospitalization was an exclusion criterion.

Main Results:

  • In-hospital mortality was 5%.
  • Median serum EPO levels were significantly higher in patients who died (78.1 vs. 9.0 I.U./ml, p=0.004).
  • EPO levels >10.5 I.U./ml were a significant predictor of acute kidney injury (AKI) development (AUC 0.73).

Conclusions:

  • Admission serum EPO levels may serve as an important biomarker for predicting AKI development in ACS patients.
  • Elevated EPO levels at admission are associated with increased in-hospital mortality in ACS patients.
  • EPO may play a role in the pathophysiology of AKI in the context of ACS.
Abstract

Keywords:
acute coronary syndromeacute heart failureacute kidney injurybiomarkerserythropoietinprognosis

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