The Correlation Between Pre-treatment Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Parameters...

To compare standardized uptake values (SUV) derived from pre-treatment ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging and clinical prognostic factors in pediatric patients with Hodgkin lymphoma (HL).

Pre-treatment FDG PET/CT findings of 28 children with HL were evaluated in this retrospective study. Metabolic tumor volume (MTV), SUV_max normalized by weight (SUV_weight), lean body mass (SUV_lbm), body surface area (SUV_bsa) and plasma glucose levels of tumors (SUV_glucose) were calculated using pre-treatment FDG PET/CT scan images. These metabolic parameters were correlated with clinical factors [age, sex, number of lymph node groups, presence of splenic involvement, bulky mediastinal disease, Ann Arbor stage, serum white blood cell (WBC) count, erythrocyte sedimentation rate (ESR), serum albumin and hemoglobin levels].

SUV_bsa, SUV_lbm, SUV_weight, SUV_glucose and MTV were higher in patients with stage III-IV disease, bulky tumor and ≥3 lymph node groups (p<0.05). SUV_bsa and SUV_glucose were higher in patients with splenic involvement (p<0.05). There was no significant correlation between these metabolic parameters and sex, ESR, levels of albumin and WBC (p>0.05). SUV_bsa and SUV_lbm were higher in patients with anemia (p<0.05). Additionally, significant increases were detected in SUV_weight, MTV, and SUV_glucose with increasing age (p=0.005, p=0.027, and p=0.009, respectively). SUV_bsa and SUV_lbm had no significant correlation with age (p>0.05).

Metabolic parameters derived from pre-treatment FDG PET/CT may have an important role in predicting high-risk disease in patients with HL. Also, SUV_bsa and SUV_lbm may be better markers than SUV_weight in the quantitative evaluation of FDG PET/CT scans in pediatric patients.