Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fractures: Bone Repair01:27

Fractures: Bone Repair

6.1K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
6.1K
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

1.5K
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
1.5K
Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

873
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
873
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

1.0K
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Double-Convex Peroneal Tubercle Morphology and MRI-Detected Peroneal Tendon Abnormality in a Non-Lateral Referral Cohort.

Diagnostics (Basel, Switzerland)·2026
Same author

Sulforaphane Against the Metabolic Consequences of a High-Glycemic-Index Diet: Protective and Therapeutic Mechanisms Associated with Obesity and Insulin Resistance.

Nutrients·2026
Same author

Virtual reality intervention for visual perception in schizophrenia-a single blind pilot randomized controlled trial.

BMC psychiatry·2025
Same author

The Relationship Between Tramadol-Induced Oxidative Testis Injury and Reproductive Function Disorder and Adenosine Triphosphate.

Life (Basel, Switzerland)·2025
Same author

Risk assessment with the fuzzy Fine-Kinney method in a business operating in the metal industry.

International journal of occupational safety and ergonomics : JOSE·2025
Same author

Pathogenesis-directed therapy of methylphenidate-induced oxidative heart damage in rats.

Frontiers in pharmacology·2025

Related Experiment Video

Updated: Mar 6, 2026

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
04:19

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device

Published on: November 8, 2024

1.5K

Pregabalin does not affect fracture healing adversely.

Nizamettin Koçkara1, Hakan Sofu, Ahmet Issin

  • 1Department of Orthopedics and Traumatology, Medical Faculty of Erzincan University, 24100 Erzincan, Turkey. nzmttn@yahoo.com.

Eklem Hastaliklari Ve Cerrahisi = Joint Diseases & Related Surgery
|March 15, 2017
PubMed
Summary

Pregabalin did not negatively impact bone fracture healing in rats. This study found no significant adverse effects on radiographic, histological, or biomechanical outcomes in femur fracture healing following pregabalin administration.

More Related Videos

Assessment of Bone Fracture Healing Using Micro-Computed Tomography
12:04

Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

2.6K
Protocol for Developing a Femur Osteotomy Model in Wistar Albino Rats
05:43

Protocol for Developing a Femur Osteotomy Model in Wistar Albino Rats

Published on: August 31, 2022

3.5K

Related Experiment Videos

Last Updated: Mar 6, 2026

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
04:19

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device

Published on: November 8, 2024

1.5K
Assessment of Bone Fracture Healing Using Micro-Computed Tomography
12:04

Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

2.6K
Protocol for Developing a Femur Osteotomy Model in Wistar Albino Rats
05:43

Protocol for Developing a Femur Osteotomy Model in Wistar Albino Rats

Published on: August 31, 2022

3.5K

Area of Science:

  • Orthopedic Surgery
  • Pharmacology
  • Regenerative Medicine

Background:

  • Fracture healing is a complex biological process.
  • Pharmacological interventions are explored to optimize bone repair.
  • The effects of pregabalin on fracture healing require investigation.

Purpose of the Study:

  • To evaluate the radiographic, histological, and biomechanical effects of pregabalin on femur fracture healing in a rat model.
  • To determine if pregabalin administration influences the bone healing cascade.

Main Methods:

  • 32 female Wistar-Albino rats were randomized into control and pregabalin treatment groups.
  • Femur fractures were induced, and drugs were administered via oral gavage.
  • Radiographic, histological, and biomechanical assessments were performed at 15 and 30 days post-surgery.

Main Results:

  • Radiographic findings showed transiently better outcomes in control groups at day 15, but no significant differences by day 30.
  • Histological and biomechanical evaluations revealed no statistically significant differences between pregabalin-treated and control groups at either time point.

Conclusions:

  • Pregabalin administration did not adversely affect the fracture healing process in this rat model.
  • The findings suggest pregabalin does not impede bone repair based on the evaluated parameters.