Related Experiment Video
Updated: Mar 6, 2026

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
Published on: May 21, 2017
Indexed left atrial size predicts all-cause and cardiovascular mortality in patients undergoing aortic valve surgery
Victor X Mosquera1, Alberto Bouzas-Mosquera2, Miguel González-Barbeito1
1Department of Cardiac Surgery, Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain.
Insights
Enlarged left atrial diameter predicts poor outcomes in patients after aortic valve surgery. This measurement is a strong indicator of mortality and stroke risk, guiding clinical decisions.
Area of Science:
- Cardiology
- Echocardiography
- Cardiac Surgery
Background:
- Left atrial enlargement is linked to increased left ventricular filling pressure and diastolic dysfunction.
- It serves as a critical marker for adverse cardiovascular events.
Purpose of the Study:
- To assess the association between indexed left atrial diameter and stroke, cardiovascular mortality, and all-cause mortality.
- To evaluate the predictive value of left atrial size in patients undergoing aortic valve surgery.
Main Methods:
- Indexed left atrial diameter was measured in 2011 adult patients undergoing aortic valve surgery.
- Outcomes including stroke, cardiovascular death, and all-cause mortality were tracked over a mean follow-up of 3.2 years.
Main Results:
- A significant proportion of patients (36%) exhibited mild to severe left atrial enlargement.
- Five-year cardiovascular mortality survival decreased significantly with increasing left atrial enlargement.
- Indexed left atrial diameter independently predicted all-cause mortality, cardiovascular death, and combined adverse events.
Conclusions:
- Indexed left atrial diameter is a robust predictor of long-term outcomes in patients with aortic valve disease undergoing surgery.
- This echocardiographic parameter provides valuable prognostic information for surgical patients.
Objectives:
The enlargement of the left atrium has been identified as a marker of chronically increased left ventricular filling pressure and left ventricular diastolic dysfunction. This study aims to evaluate the association of indexed left atrial diameter with stroke, cardiovascular mortality, the combined event, and all-cause mortality in patients who underwent aortic valve surgery.
Methods:
Indexed left atrial diameter was measured in 2011 adult patients (mean age, 70.9 ± 10.8 years; 58.7% were men) who underwent aortic valve surgery between January 2008 and March 2016.
Results:
On the basis of the criteria of the American Society of Echocardiography, indexed left atrial diameter was normal in 64% of patients, mildly enlarged in 12.4% of patients, moderately enlarged in 9.2% of patients, and severely enlarged in 14.3% of patients. Over a mean follow-up period of 3.2 ± 2.1 years, there were 334 deaths and 97 strokes. Cardiovascular mortality survival at 5 years among patients with normal, mild, moderate, and severe left atrial enlargement was 91.6%, 86.8%, 77.9%, and 77.4%, respectively (P < .001). After covariable adjustment, Cox regression analysis showed indexed left atrial diameter as an independent predictor of all-cause mortality (hazard ratio per 1-cm/m2 increment, 1.545; 95% confidence interval, 1.252-1.906, P < .001), cardiovascular death (hazard ratio per 1-cm/m2 increment, 1.971; 95% confidence interval, 1.541-2.520; P < .001), and the combined event (hazard ratio per 1-cm/m2 increment, 1.673; 95% confidence interval, 1.321-2.119; P < .001).
Conclusions:
Indexed left atrial diameter is a strong predictor of long-term outcomes in patients with aortic valve diseases who undergo surgery.
More Related Videos
Related Concept Videos
Aortic Regurgitation III: Medical Management
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Aneurysm III: Interprofessional Care
Aortic Regurgitation I: Introduction
Mitral Valve Prolapse II: Assessment and Management

