Endothelial progenitor cells in chronic obstructive pulmonary disease and emphysema
Margaret F Doyle1, Russell P Tracy1, Megha A Parikh2
1Department of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont, United States of America.
Plos One
|March 15, 2017
Summary
Endothelial progenitor cells, crucial for blood vessel repair, are decreased in COPD patients, particularly those with emphysema. Circulating endothelial cells, indicating injury, were not elevated in COPD but linked to reduced lung blood flow.
Area of Science:
- Pulmonary Medicine
- Vascular Biology
- Cellular Biology
Background:
- Endothelial injury is key in COPD and emphysema pathogenesis.
- The roles of endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs) in COPD are unclear.
- EPCs signify endothelial repair, while CECs indicate injury.
Purpose of the Study:
- To investigate EPC and CEC levels in COPD and emphysema.
- To determine associations between EPCs/CECs and COPD subphenotypes.
- To test the hypothesis that EPCs decrease and CECs increase in COPD.
Main Methods:
- Recruited 257 smokers with COPD and controls (Multi-Ethnic Study of Atherosclerosis COPD Study).
- Measured EPCs (CD34+KDR+, CD34+KDR+CD133+) and CECs (CD45dimCD31+CD146+CD133-) via flow cytometry.
- Assessed COPD by spirometry, emphysema by CT, and pulmonary function.
Main Results:
- COPD patients showed reduced EPC populations, especially CD34+KDR+ cells.
- CD34+KDR+CD133+ EPCs correlated inversely with emphysema extent.
- EPCs correlated inversely with panlobular emphysema and positively with diffusing capacity.
- CECs were not significantly altered in COPD but inversely associated with microvascular blood flow.
Conclusions:
- Endothelial repair is impaired in COPD.
- This impairment appears specific to the emphysema subphenotype.
- EPC dysfunction may contribute to COPD pathogenesis, particularly in emphysema.
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