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Published on: June 28, 2021
Tamoxifen use and acute pancreatitis: A population-based cohort study
Fan-Gen Hsu1,2, Yow-Wen Hsieh1,2, Ming-Jyh Sheu1
1School of Pharmacy, China Medical University, Taichung, Taiwan.
This study found no significant link between tamoxifen use and acute pancreatitis (AP) risk in breast cancer patients. Further research confirms tamoxifen is not associated with developing AP.
Area of Science:
- Oncology
- Pharmacology
- Gastroenterology
Background:
- Case reports suggest tamoxifen may induce acute pancreatitis (AP).
- Lack of pharmacoepidemiological data to support this association.
- Need to investigate tamoxifen's role in AP risk among breast cancer patients.
Purpose of the Study:
- To determine if tamoxifen use correlates with an increased risk of acute pancreatitis (AP).
- To analyze pharmacoepidemiological data for tamoxifen-induced AP in breast cancer patients.
Main Methods:
- Population-based cohort study utilizing the Taiwan National Health Insurance Research Database.
- Included 22,005 breast cancer patients (≥20 years) from 2000-2009.
- Time-dependent Cox proportional hazard models and propensity score-matched cohorts analyzed AP risk and tamoxifen use.
Main Results:
- No significant correlation between tamoxifen use and AP risk (adjusted HR = 0.94; 95% CI = 0.74-1.19).
- No dose-response trend observed between tamoxifen use and AP risk (adjusted HR = 0.98; 95% CI = 0.96-1.00).
- Diabetes Mellitus and gallstones were identified as significant risk factors for AP.
Conclusions:
- Tamoxifen use is not significantly correlated with an increased risk of acute pancreatitis in breast cancer patients.
- The study provides pharmacoepidemiological evidence against a causal link between tamoxifen and AP.
- Comorbidities like DM and gallstones remain key risk factors for AP.
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