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Green tea and its anti-angiogenesis effects.

Bahman Rashidi1, Mehrnoush Malekzadeh1, Mohammad Goodarzi2

  • 1Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|March 16, 2017
PubMed
Summary

Green tea compounds, particularly EGCG, inhibit pathological angiogenesis by targeting the VEGF family and altering microRNA profiles. This suggests potential therapeutic applications for cancer and other diseases driven by abnormal blood vessel growth.

Keywords:
AngiogenesisEpigallocatechin-3-gallateGreen teaMicroRNAVEGF

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Angiogenesis, the formation of new blood vessels, is crucial for development but also drives diseases like cancer.
  • The vascular endothelial growth factor (VEGF) family and their receptors are key regulators of angiogenesis and targets for anti-angiogenic therapies.
  • Pathological angiogenesis is implicated in cancer, inflammatory, and ischemic diseases.

Purpose of the Study:

  • To review the mechanisms by which green tea constituents, especially EGCG, suppress angiogenesis signaling.
  • To highlight the role of green tea in modulating microRNA (miRNA) expression related to anti-angiogenesis.
  • To explore the potential of green tea polyphenols as anti-angiogenic agents.

Main Methods:

  • Literature review focusing on the molecular mechanisms of green tea's anti-angiogenic effects.
  • Analysis of studies investigating the impact of green tea polyphenols, particularly EGCG, on VEGF signaling pathways.
  • Examination of research on green tea-mediated alterations in miRNA expression profiles relevant to angiogenesis.

Main Results:

  • Green tea polyphenols, including EGCG, demonstrate the ability to inhibit angiogenesis through various mechanisms.
  • EGCG can interfere with the VEGF signaling pathway, a critical target for anti-angiogenic drugs.
  • Green tea consumption alters miRNA expression profiles, influencing pathways involved in suppressing angiogenesis.

Conclusions:

  • Green tea constituents possess significant anti-angiogenic properties, acting on key molecular targets like the VEGF family.
  • The modulation of miRNA expression by green tea offers a novel mechanism for controlling pathological angiogenesis.
  • Green tea and its components, particularly EGCG, show promise as chemo-preventive and chemotherapeutic agents for angiogenesis-dependent diseases.