Related Experiment Video

Updated: Mar 6, 2026

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
08:08

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

17.1K

Focus Issue: Cancer-Beyond tumor genetics to protein landscapes

Leslie K Ferrarelli1, Nancy R Gough2

  • 1Associate Editor, Science Signaling, AAAS, Washington, DC 20005, USA. lferrare@aaas.org.

Science Signaling
|March 16, 2017
PubMed

Insights

This research explores cancer therapeutic targets by analyzing protein profiles in both tumors and their microenvironments. Understanding these protein landscapes is crucial for developing effective cancer treatments.

Area of Science:

  • Oncology
  • Proteomics
  • Genomics

Background:

  • Cancer therapies often target proteins regulating cell proliferation, metastasis, survival, and immune evasion.
  • Genomic profiling solely of cancer cells overlooks the critical tumor microenvironment.
  • Aberrant signaling in cancer requires comprehensive protein analysis for effective therapeutic targeting.

Discussion:

  • This Focus Issue highlights translating genomic data into therapeutically targetable aberrant signaling.
  • Strategies are presented to analyze protein landscapes within tumors.
  • Emphasis is placed on investigating protein profiles of the tumor microenvironment.

Key Insights:

  • Integrating genomic and proteomic data enhances understanding of cancer signaling pathways.
  • Analyzing the tumor microenvironment's protein profile is essential for comprehensive cancer research.
  • Targeting aberrant signaling requires a holistic view of tumor and microenvironment proteins.

Outlook:

  • Future cancer therapies may leverage combined genomic and proteomic analyses of tumors and their microenvironments.
  • Developing novel therapeutic strategies requires a deeper understanding of protein dynamics in cancer.
  • This work paves the way for more precise and effective cancer interventions.

More Related Videos

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies09:01

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies

Published on: July 3, 2025

1.1K
An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

10.9K

Related Concept Videos

Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
10.0K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
7.2K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.0K
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
15.2K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
11.7K