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Novel adipokines: methodological utility in human obesity research
F Eichelmann1, N Rudovich2,3,4,5, A F Pfeiffer2,3,5
1Nutrition, Immunity and Metabolism Start-up Lab, Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.
International Journal of Obesity (2005)
|March 16, 2017
Summary
This study shows that key adipokines, or fat-derived proteins, are reliably measurable over time. These results support using single measurements of these biomarkers in obesity and metabolic disease research.
Area of Science:
- Biochemistry
- Metabolic Research
- Obesity Studies
Background:
- Adipokines link adiposity, inflammation, and metabolic disease risk.
- Methodological suitability of adipokine biomarkers in human obesity research is unclear.
Purpose of the Study:
- To assess the intra-individual reproducibility of selected adipokines over a 4-month period.
- To determine the reliability of adipokine measurements for human obesity research.
Main Methods:
- Assessed reproducibility in 207 apparently healthy participants.
- Measured concentrations of FABP-4, lipocalin-2, MCP-1, procalcitonin, progranulin, and vaspin.
- Utilized intraclass correlation coefficients (ICC) and Bland-Altman plots.
Main Results:
- Good to excellent reproducibility observed for most adipokines (FABP-4, lipocalin-2, MCP-1, procalcitonin, progranulin, vaspin).
- Intraclass correlation coefficients (ICC) ranged from 0.59 to 0.86.
- Bland-Altman plots confirmed good agreement between repeated measurements.
Conclusions:
- Single measurements of evaluated adipokines are suitable for population-based studies.
- Supports the use of these biomarkers in research on obesity, inflammation, and metabolic diseases.
