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Serum calreticulin as a novel biomarker of juvenile idiopathic arthritis disease activity

Nashwa Ismail Hashaad1, Rasha Mohamed Fawzy1, Abeer Ahmed Abo Elazem2

  • 1Department of Rheumatology, Rehabilitation and Physical Medicine, Benha University School of Medicine, Benha, Egypt.

European Journal of Rheumatology
|March 16, 2017
PubMed

Insights

Elevated serum calreticulin (CRT) levels are significantly higher in children with juvenile idiopathic arthritis (JIA). These elevated CRT levels correlate with disease activity and severity, suggesting CRT as a potential biomarker for JIA.

Area of Science:

  • Rheumatology
  • Immunology
  • Biochemistry

Background:

  • Juvenile idiopathic arthritis (JIA) is a chronic autoimmune disease affecting children.
  • Accurate biomarkers for JIA disease activity and severity are crucial for effective management.

Purpose of the Study:

  • To investigate the relationship between serum calreticulin (CRT) levels and disease activity/severity in JIA patients.

Main Methods:

  • Serum CRT levels were measured using ELISA in 60 JIA patients and 50 healthy controls.
  • Disease activity was assessed using the juvenile arthritis disease activity score 27 (JADAS-27).
  • Disease severity was evaluated using ultrasonography (US) and power Doppler US (PDUS).

Main Results:

  • Mean serum CRT levels were significantly higher in JIA patients (8.6±1.2 ng/mL) compared to controls (5.02±0.77 ng/mL) (p=0.001).
  • Serum CRT levels showed significant positive correlations with disease duration, joint counts, visual analog scale, ESR, JADAS-27, CRP, RF titer, and ultrasonographic findings (synovitis, neovascularization).

Conclusions:

  • Elevated serum CRT levels are associated with JIA.
  • CRT may serve as a novel biomarker for assessing disease activity and severity in juvenile idiopathic arthritis.
Abstract

Keywords:
Juvenile idiopathic arthritisactivity scorecalreticulinsynovitis

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