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Structural and functional hyperconnectivity within the sensorimotor system in xenomelia.

Jürgen Hänggi1, Deborah A Vitacco2, Leonie M Hilti2

  • 1Division Neuropsychology Department of Psychology University of Zurich Zurich Switzerland.

Brain and Behavior
|March 16, 2017
PubMed
Summary
This summary is machine-generated.

Xenomelia, a rare condition causing a desire for limb amputation, shows increased brain connectivity in the sensorimotor system. This study reveals structural and functional hyperconnectivity in xenomelia patients, particularly in the right hemisphere.

Keywords:
body integrity identity disorderdiffusion tensor imaginglimb amputationresting state functional magnetic resonance imagingsensorymotor systemstructural and functional hyperconnectivity

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Psychiatry

Background:

  • Xenomelia is a rare condition characterized by a compulsive desire for amputation of healthy limbs.
  • Understanding the neurological basis of xenomelia is crucial for developing targeted interventions.

Purpose of the Study:

  • To investigate the neurological underpinnings of xenomelia by assessing structural and functional brain connectivity.
  • To identify specific brain regions and networks associated with the condition.

Main Methods:

  • Compared 13 men with xenomelia to matched controls using diffusion tensor imaging and resting-state functional MRI.
  • Employed whole-brain connectome and network analyses to examine structural and functional connectivity.

Main Results:

  • Found subnetworks with structural and functional hyperconnectivity in xenomelia patients, predominantly in the right hemisphere's sensorimotor system.
  • Identified specific hyperconnected regions including the paracentral lobule, supplementary motor area, basal ganglia, and cerebellum.

Conclusions:

  • Provides empirical evidence for structural and functional hyperconnectivity within the sensorimotor system in xenomelia.
  • Suggests aberrant connectivity may underlie the body image disturbances in xenomelia, warranting further research.