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Paget's disease of the breast
R S du Toit1, P S van Rensburg, L Goedhals
1Department of Surgery, University of the Orange Free State, Bloemfontein.
Summary
Paget
Area of Science:
- Oncology
- Pathology
Background:
- Paget's disease of the breast is a rare condition.
- It is often associated with underlying breast cancer.
Purpose of the Study:
- To review the clinical presentation, treatment, and outcomes of patients with Paget's disease of the breast.
- To identify predictors of prognosis in these patients.
Main Methods:
- Retrospective review of 20 patients with Paget's disease of the breast.
- Analysis of clinical presentation, tumor characteristics, treatment, and survival data.
Main Results:
- Paget's disease of the breast occurred in 1.06% of breast carcinomas.
- Patients presenting with a mass had higher rates of lymph node involvement than those with nipple disease only.
- Tumor size and lymph node involvement were key prognostic factors.
- Survival rates were 100% for nipple disease only, 83% for stage I/II disease, and 0% for stage III/IV disease.
Conclusions:
- Paget's disease of the breast requires careful staging and risk stratification.
- Tumor size and lymph node status are critical for prognosis.
- Consideration for less invasive treatment options for select patients with nipple involvement only or small T1 lesions.