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The Intriguing Link between the Intestinal Microbiota and Cardiovascular Disease
Giuseppe Lippi1, Elisa Danese1, Camilla Mattiuzzi2
1Section of Clinical Biochemistry, University of Verona, Verona, Italy.
Seminars in Thrombosis and Hemostasis
|March 16, 2017
Summary
The human gut microbiota influences cardiovascular disease risk. Trimethylamine-N-oxide (TMAO)-producing bacteria are linked to increased TMAO levels and higher risks of ischemic and thrombotic disorders.
Area of Science:
- Microbiology
- Human Health
- Cardiovascular Science
Background:
- The human microbiota, primarily in the gut, significantly impacts health.
- Technological advances enable detailed characterization of microbial communities and disease links.
- Growing evidence links gut microbiota composition to cardiovascular disease (CVD) risk.
Purpose of the Study:
- To explore the relationship between gut microbiota and cardiovascular disease.
- To highlight the role of specific bacteria in CVD development.
Main Methods:
- Analysis of gut microbiota composition.
- Investigation of trimethylamine-N-oxide (TMAO)-producing bacteria.
- Correlation studies between microbial profiles, TMAO levels, and cardiovascular events.
Main Results:
- Certain gut bacteria produce trimethylamine-N-oxide (TMAO).
- Elevated TMAO levels are associated with increased risk of ischemic and thrombotic disorders.
- Gut microbiota composition is a significant factor in cardiovascular risk.
Conclusions:
- Targeting the gut microbiota offers potential strategies for CVD prevention.
- Interventions may include dietary changes, probiotics, prebiotics, antibiotics, or microbial transplantation.
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