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β-Amyrin biosynthesis: catalytic mechanism and substrate recognition

Tsutomu Hoshino1

  • 1Graduate School of Science and Technology and Department of Applied Biological Chemistry, Faculty of Agriculture, Niigata University, Ikarashi 2-8050, Nishi-ku, Niigata 950-2181, Japan. hoshitsu@agr.niigata-u.ac.jp.

Organic & Biomolecular Chemistry
|March 16, 2017
PubMed
Summary

Oxidosqualene cyclases (OSCs) generate diverse sterols and triterpenoids. This review details advances in understanding beta-amyrin synthase, comparing its mechanism and substrate recognition to related enzymes like lanosterol synthase and squalene-hopene cyclase.

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