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Related Experiment Videos

[Activation of gamma-interferonogenesis].

V P Kuznetsov, I V Korobko, V Ia Arion

    Voprosy Virusologii
    |September 1, 1987
    PubMed
    Summary

    Priming with interferons (IFN-gamma, IFN-alpha), T-activin, or B vitamins significantly boosts gamma-interferon production. Maximal yields were achieved with specific priming doses of IFN-gamma or IFN-alpha.

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    Production of Recombinant Proteins in the Milk of Transgenic Animals: Current State and Prospects.

    Acta naturae·2018

    Area of Science:

    • Immunology
    • Cell Biology

    Context:

    • Interferons (IFNs) are crucial cytokines in the innate and adaptive immune response.
    • Modulating immune cell function is key for therapeutic applications.

    Purpose:

    • To investigate methods for enhancing gamma-interferon (IFN-gamma) production.
    • To evaluate the efficacy of various priming agents on IFN-gamma yield.

    Summary:

    • Priming with homologous gamma-interferon (IFN-gamma) or alpha-interferon (IFN-alpha) significantly increased IFN-gamma production.
    • T-activin and B vitamins (specifically vitamin B12) also demonstrated a notable enhancement in IFN-gamma yield.
    • Maximal IFN-gamma yields (up to 10,000 IU/ml) were achieved using specific priming doses of IFN-gamma (5 IU/ml) or IFN-alpha (1000 IU/ml).
    • Combined application of priming agents, T-activin, and vitamin B12 did not result in further yield increases.

    Impact:

    • Identifies effective strategies for boosting IFN-gamma production in vitro.
    • Provides optimal priming conditions for maximizing IFN-gamma yields.
    • Potential implications for immunotherapy and research involving IFN-gamma.

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