Related Experiment Video
Updated: Mar 6, 2026

Novel and Innovative Hybrid Technique for Type A Aortic Dissection
Published on: March 28, 2025
Peripartum type B aortic dissection in patients with Marfan syndrome who underwent aortic root replacement: a case
Objective:
To investigate pregnancy outcomes, especially the risk of pregnancy-related aortic dissection (AD), in patients with Marfan syndrome (MFS) after prophylactic aortic root replacement (ARR).
Design:
Retrospective case series study.
Setting:
Tertiary perinatal care centre at a university hospital.
Population:
Pregnant women fulfilling the revised Ghent nosology (2010) criteria for MFS who were managed at our institute.
Methods:
The pregnancy outcomes of all patients with MFS managed at our institute between 1982 and September 2016 were reviewed retrospectively based on medical records.
Main Outcome Measures:
Obstetrical management and complication including the incidence of AD throughout the peripartum period.
Results:
Among 22 patients (28 pregnancies) who had been managed as potential MFS or related disorders, 14 (17 pregnancies) fulfilled the revised Ghent nosology (2010) criteria for MFS and were enrolled in this study. Five patients (five pregnancies) had received ARR before conception: three (60%) developed type B aortic dissection [AD(B)] during the peripartum period, compared with only one of 10 patients (12 pregnancies) without ARR (P < 0.05, Chi-square test).
Conclusions:
Our study results suggest that MFS patients after prophylactic ARR are still at high risk of AD(B) during the peripartum period. Careful pre-pregnancy counselling and multidisciplinary care throughout the peripartum period are essential for the management of MFS, even after surgical repair of an ascending aortic aneurysm.
Tweetable Abstract:
MFS patients after prophylactic ARR are still at high risk of type B aortic dissection during the peripartum period.
Related Concept Videos
Aneurysm I: Introduction
Aneurysm III: Interprofessional Care
Aortic Regurgitation III: Medical Management
Aortic Regurgitation I: Introduction
Aneurysm IV: Nursing Management
Aortic Regurgitation II: Clinical Features and Diagnostic Tests

