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Sleep Patterns and Neuropsychiatric Symptoms in Hospitalized Patients With Dementia
Kaloyan S Tanev1, Andrew Winokur1, Roger K Pitman1
1From the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (KST, RKP); and the Department of Psychiatry, University of Connecticut Health Center, Farmington, Conn. (AW).
Abstract:
The authors examined 28 dementia inpatients receiving treatment as usual. Beginning-to-end differences in neuropsychiatric symptoms and actigraphic sleep patterns were measured. Using a mixed-model, the authors regressed neuropsychiatric symptoms on average sleep minutes (between-subjects effect) and each night's deviation from average (within-subject effect). Sleep did not significantly differ from beginning to end of participation, whereas neuropsychiatric symptoms did. Average sleep minutes predicted average neuropsychiatric symptoms (p=0.002), but each night's deviation from the average did not predict next day's symptoms (p=0.90). These findings raise questions about the immediate benefits of treating sleep-wake disturbances on neuropsychiatric symptoms in hospitalized inpatients with dementias.
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