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Updated: Mar 6, 2026

Prehospital Thrombolysis: A Manual from Berlin
Published on: November 26, 2013
[Type of Thrombolytic Agent and Rate of Acute Kidney Injury in Patients With Myocardial Infarction]
M V Menzorov1, A M Shutov1, V A Serov1
1Department of Internal Medicine, Ulyanovsk State University, ul. Architect Livchaka, 2/1, 432063 Ulyanovsk, Russia.
Abstract:
Aim of this study was to assess incidence and severity of acute kidney injury (AKI) in patients with ST-elevation (STE) myocardial infarction (MI) after thrombolytic therapy with alteplase or streptokinase. Among 292 included patients (227 men, 65 women, mean age 58+/-11 years) 170 received streptokinase, 122 - alteplase. Coronary angiography in acute stage of MI was an exclusion criterion. Thrombolysis was effective in 213 (73%) patients. There was no statistically significant difference in effectiveness of thrombolysis among streptokinase or alteplase treated patients. Incidence of AKI in patients with STEMI was 25%. Both incidence and severity of AKI were higher in streptokinase treated patients. Only stage II-III AKI was significantly associated with higher in-hospital mortality.
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