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Upper gastrointestinal carcinoma in familial polyposis. Case report
1Department of Surgery, Malmö General Hospital, Sweden.
Acta Chirurgica Scandinavica
|October 1, 1987
Summary
Familial polyposis coli patients require lifelong upper gastrointestinal surveillance. Adenocarcinoma can develop years after colectomy, highlighting the risk of extracolonic lesions in this condition.
Area of Science:
- Gastroenterology
- Oncology
- Genetics
Background:
- Familial polyposis coli (FPC) is an inherited condition predisposing individuals to numerous colorectal polyps.
- Colectomy is a standard treatment for FPC to prevent colorectal cancer.
- Extracolonic manifestations of FPC are increasingly recognized.
Observation:
- Three siblings with FPC developed upper gastrointestinal adenocarcinoma.
- Malignancy appeared many years after their colectomies.
- This suggests a prolonged risk period for extracolonic tumors.
Findings:
- The study highlights a significant risk of upper gastrointestinal adenocarcinoma in FPC patients post-colectomy.
- Adenocarcinomas developed years after the primary colectomy, indicating a delayed onset.
- Extracolonic lesions are a notable concern in the management of FPC.
Implications:
- Regular upper gastrointestinal surveillance is crucial for FPC patients even after colectomy.
- This surveillance should extend for many years post-surgery due to the delayed risk.
- Understanding extracolonic risks improves long-term management strategies for FPC.