[Renal Dysfunction in Patients With Ischemic Heart Disease]

A I Zhantudueva1, M M Batushin1, M A Umetov1

  • 1Kabardino-Balkar State University im. H.M. Berbekov, ul. Chernyshevskogo, 360004 Nalchik, Russia.

Kardiologiia
|March 16, 2017
PubMed

Insights

Patients with atrial fibrillation and exertional angina experienced the most significant cardiac abnormalities and kidney dysfunction. This highlights the severe impact of combined cardiac conditions on renal health.

Area of Science:

  • Cardiology
  • Nephrology
  • Internal Medicine

Context:

  • Coronary heart disease (CHD) encompasses various conditions affecting heart function.
  • Renal dysfunction is a potential complication of cardiovascular diseases.
  • Understanding the differential impact of specific CHD forms on kidney health is crucial.

Purpose:

  • To investigate the effects of different types of coronary heart disease on the progression of renal dysfunction.
  • To compare the severity of renal impairment in patients with exertional angina, old myocardial infarction plus exertional angina, and atrial fibrillation plus exertional angina.

Summary:

  • Three patient groups were studied: exertional angina (n=29), old myocardial infarction with exertional angina (n=22), and atrial fibrillation with exertional angina (n=21).
  • Group 3, patients with atrial fibrillation and exertional angina, exhibited the most pronounced cardiac abnormalities.
  • Statistically significant renal dysfunction was most evident in the group with atrial fibrillation and exertional angina.

Impact:

  • Identifies atrial fibrillation combined with exertional angina as a high-risk factor for significant renal dysfunction.
  • Provides evidence for differential progression of renal impairment based on specific coronary heart disease manifestations.
  • Informs clinical management strategies for patients with complex cardiovascular and renal comorbidities.

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
419
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
1.1K
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
547
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
1.3K
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
534
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
1.0K