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[Possible Choice of New Oral Anticoagulants With Non-Valvular Atrial Fibrillation: a Review of Meta-Analyzes]

B A Tatarsky1, N V Kazennova1

  • 1Northwest Medical Research Center, 197341 2, Str. Akkuratova, St. Petersburg, Russia.

Kardiologiia
|March 16, 2017
PubMed

Insights

New oral anticoagulants significantly reduce stroke, intracranial hemorrhage, and mortality in non-valvular atrial fibrillation patients. While increasing gastrointestinal bleeding, these anticoagulants offer a favorable risk-benefit profile.

Area of Science:

  • Cardiology
  • Pharmacology
  • Evidence-based Medicine

Context:

  • Non-valvular atrial fibrillation (NVAF) poses a significant risk for stroke and systemic embolism.
  • Current therapeutic strategies aim to mitigate these risks while balancing safety and efficacy.
  • Newer oral anticoagulant (NOAC) agents represent a significant advancement in anticoagulation therapy.

Purpose:

  • To conduct a meta-analysis evaluating the efficacy and safety of new oral anticoagulants (NOACs) in patients with non-valvular atrial fibrillation.
  • To compare the risk profile and efficiency of NOACs against established anticoagulation therapies.
  • To assess the consistency of NOAC efficacy and safety across diverse patient subgroups.

Summary:

  • Meta-analysis of four studies on NOACs for stroke prevention in NVAF patients.
  • NOACs demonstrated significant reductions in stroke, intracranial hemorrhage, and mortality.
  • A notable increase in gastrointestinal bleeding events was observed with NOAC use.
  • Efficacy and safety profiles of NOACs were consistent across various clinical characteristics.

Impact:

  • NOACs provide a favorable risk-benefit profile for stroke prevention in NVAF.
  • These findings support the expanded use of NOACs as a primary therapeutic option.
  • Further research may focus on mitigating gastrointestinal bleeding risks associated with NOACs.

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