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[Relationship Between Blood Serum Galectin and Renal Dysfunction in ST Elevation Myocardial Infarction]

V N Karetnikova1, A V Osokina1, M V Evseeva1

  • 11Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, Russia; 2Kemerovo State Medical Academy, Kemerovo, Russia.

Kardiologiia
|March 16, 2017
PubMed

Insights

In ST-elevation myocardial infarction (STEMI) patients, renal dysfunction (RD) and elevated galectin levels predict poor prognosis. These factors independently forecast unfavorable outcomes one year post-STEMI.

Area of Science:

  • Cardiology
  • Nephrology
  • Biochemistry

Background:

  • ST-elevation myocardial infarction (STEMI) poses significant prognostic challenges.
  • Identifying early predictors of unfavorable outcomes is crucial for patient management.
  • The role of galectin and renal dysfunction (RD) in STEMI prognosis requires further elucidation.

Purpose of the Study:

  • To evaluate the prognostic value of serum galectin and renal dysfunction (RD) markers.
  • To assess their impact on in-hospital and one-year prognosis in STEMI patients.
  • To determine the association between galectin levels and early post-infarction angina.

Main Methods:

  • Studied 128 STEMI patients using standard laboratory and instrumental examinations.
  • Calculated glomerular filtration rate (GFR) using MDRD formula and cystatin C.
  • Assessed serum galectin levels and categorized patients based on GFR (>=60 ml/min/1.73 m2 vs. <60 ml/min/1.73 m2) on day 12.

Main Results:

  • Renal dysfunction (RD), defined by GFR <60 ml/min/1.73 m2, was identified in 81 patients.
  • Elevated serum galectin (>17.8 hg/ml) on day 12 was observed.
  • RD and elevated galectin were independent predictors of unfavorable one-year prognosis in STEMI.

Conclusions:

  • Renal dysfunction and elevated serum galectin are independent predictors of poor one-year prognosis in STEMI.
  • Higher galectin levels correlate with early post-infarction angina.
  • These markers aid in risk stratification for STEMI patients.
Abstract

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