[Relationship Between Blood Serum Galectin and Renal Dysfunction in ST Elevation Myocardial Infarction]

Area of Science:

• Cardiology
• Nephrology
• Biochemistry

Background:

• ST-elevation myocardial infarction (STEMI) poses significant prognostic challenges.
• Identifying early predictors of unfavorable outcomes is crucial for patient management.
• The role of galectin and renal dysfunction (RD) in STEMI prognosis requires further elucidation.

Purpose of the Study:

• To evaluate the prognostic value of serum galectin and renal dysfunction (RD) markers.
• To assess their impact on in-hospital and one-year prognosis in STEMI patients.
• To determine the association between galectin levels and early post-infarction angina.

Main Methods:

• Studied 128 STEMI patients using standard laboratory and instrumental examinations.
• Calculated glomerular filtration rate (GFR) using MDRD formula and cystatin C.
• Assessed serum galectin levels and categorized patients based on GFR (>=60 ml/min/1.73 m2 vs. <60 ml/min/1.73 m2) on day 12.

Main Results:

• Renal dysfunction (RD), defined by GFR <60 ml/min/1.73 m2, was identified in 81 patients.
• Elevated serum galectin (>17.8 hg/ml) on day 12 was observed.
• RD and elevated galectin were independent predictors of unfavorable one-year prognosis in STEMI.

Conclusions:

• Renal dysfunction and elevated serum galectin are independent predictors of poor one-year prognosis in STEMI.
• Higher galectin levels correlate with early post-infarction angina.
• These markers aid in risk stratification for STEMI patients.