Related Experiment Video
Updated: Mar 3, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
[Comparative Prospective Clinical Economic Study of Original and Generic Bisoprolol in Patients With Coronary Heart
E I Tarlovskaya1, T I Chudinovskih1
11Nizhny Novgorod State Medical Academy, Nizhny Novgorod, Russia: 2Kirov State Medical Academy Kirov, Russia.
Purpose:
to conduct comparative clinical and economical analysis of original and generic preparations of bisoprolol.
Materials And Methods:
The study included 61 patients after acute coronary syndrome (ACS) (34 men, 27 women, age 46-78 years). Patients were distributed (envelope method) to 2 groups. Patients of group A received original bisoprolol, of group C - generic drug. Duration of observation was 6 weeks. Parameters analyzed were dynamics of heart rate (HR), data of treadmill exercise test, and values of calculated cost/effectiveness ratio.
Results:
In both groups we observed significant slowing of HR. Data of treadmill test showed similar increases of volume of work.
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