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Updated: Oct 13, 2025

Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration
Published on: April 4, 2022
[Thiotriazoline in the Treatment of Stable Angina IIIII Functional Class]
D V Kadin1, B A Chumak1, A E Filippov1
11S.. Kirov St. Petersburg Military medical academy, St. Petersburg, Russia; 2St.Petersburg State University, St. Petersburg, Russia.
Abstract:
Trimetazidine is a metabolic agent of proven efficacy in improving myocardial ischemia and angina. A comparative international multicenter randomized trial, assessed anti-anginal anti ischemic efficacy and safety of Trimetazidine (60 mg/d) and Thiotriazoline (600 mg/d) in symptomatic patients with chronic ischemic heart disease receiving the first line therapy. The study assessed the efficacy of the two drugs on total exercise duration, time to 1-mm ST segment depression, the number of angina attacks and nitroglycerin tablets consumed amount. Both drugs have demonstrated clinical efficacy equal for all primary and secondary endpoints.
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