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Expression of MHC class I genes in mouse hepatitis virus (MHV-A59) infection and in multiple sclerosis
E Lavi1, A Suzumura, L A Lampson
1Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia.
Advances in Experimental Medicine and Biology
|January 1, 1987
Abstract:
Our studies revealed that virus induced demyelination as well as human inflammatory demyelination involves upregulation of class I MHC genes and surface expression of antigens encoded by these genes. Induction involves the action of an intermediate soluble factor/s which is at present unknown. These findings suggest that MHC class I restricted, cytotoxic T lymphocyte (CTL) reactions, against self or foreign antigens may play a role in these conditions. These findings may help to elucidate the mechanism of coronavirus-induced demyelination as well as the pathogenesis of multiple sclerosis.