Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

4.8K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
4.8K
Exercise and Cardiac Output01:17

Exercise and Cardiac Output

2.3K
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
2.3K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

1.2K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.2K
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

558
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
558
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

847
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
847
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

786
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
786

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Loss of NRF2 During Aging Contributes to Myocardial Functional Decline.

Antioxidants (Basel, Switzerland)·2026
Same author

Slc1a2-mediated Glutamate Transport Promotes Dendritic Cell Immunity through Sema3A-regulated Cytoskeletal Remodeling and Migration.

International journal of biological sciences·2026
Same author

Sweetening the bonds: how O-GlcNAcylation modulates cell adhesion.

Acta pharmacologica Sinica·2026
Same author

Analysis of the application effect of an automated eye position fixation training device in patients undergoing pterygium surgery: a two-year follow-up randomized controlled trial.

Frontiers in medicine·2026
Same author

Comment on "Use of intracameral antibiotics prophylaxis in patients with posterior capsular rupture during cataract surgery: systematic review and meta-analysis".

Journal of cataract and refractive surgery·2026
Same author

Targeted next-generation sequencing reveals pathogen spectrum, drug resistance characteristics, and clinical determinants in children with community-acquired pneumonia.

Translational pediatrics·2026

Related Experiment Video

Updated: Mar 6, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

13.3K

Exercise training reverses age-induced diastolic dysfunction and restores coronary microvascular function.

Kazuki Hotta1, Bei Chen2, Bradley J Behnke3

  • 1Department of Biomedical Sciences, Florida State University, Tallahassee, FL, USA.

The Journal of Physiology
|March 16, 2017
PubMed
Summary

Late-life exercise training reverses age-related diastolic dysfunction and microvascular decline in rats. This suggests that exercise can improve heart function and coronary blood flow in older individuals.

Keywords:
E/Aaortic stiffnesscoronary arteriolesendotheliumrat

More Related Videos

Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine
12:37

Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine

Published on: February 9, 2016

14.0K
Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
10:00

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Published on: March 15, 2019

8.9K

Related Experiment Videos

Last Updated: Mar 6, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

13.3K
Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine
12:37

Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine

Published on: February 9, 2016

14.0K
Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
10:00

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Published on: March 15, 2019

8.9K

Area of Science:

  • Cardiovascular Physiology
  • Gerontology
  • Exercise Science

Background:

  • Diastolic dysfunction risk increases with age.
  • Exercise training can improve age-related diastolic dysfunction, but mechanisms are unclear.
  • Microvascular dysfunction may contribute to age-related diastolic dysfunction.

Purpose of the Study:

  • To investigate if microvascular dysfunction contributes to age-related diastolic dysfunction.
  • To determine if late-life exercise training reverses age-related diastolic and microvascular dysfunction.

Main Methods:

  • Young and old rats underwent 10 weeks of exercise training or remained sedentary.
  • Evaluated isovolumic relaxation time (IVRT), early diastolic filling (E/A), myocardial performance index (MPI), and aortic stiffness (PWV).
  • Assessed coronary blood flow and coronary arteriole vasodilatory responses.

Main Results:

  • Aged sedentary rats showed impaired diastolic function (increased IVRT, decreased E/A) and reduced coronary blood flow and vasodilation.
  • Exercise training normalized IVRT and E/A in aged rats.
  • Exercise training reversed age-related impairments in coronary blood flow and endothelial function.

Conclusions:

  • Age-related diastolic dysfunction is linked to microvascular dysfunction and reduced coronary perfusion.
  • Late-life exercise training effectively reverses age-related diastolic and microvascular dysfunction.
  • Improved endothelial function may underlie the benefits of exercise training on coronary microvascular function.