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Liver Histology

Liver Histology

The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...

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Interobserver Agreement Using Histological Scoring of the Canine Liver.

J A Lidbury¹, A Rodrigues Hoffmann², R Ivanek³

¹Gastrointestinal Laboratory, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX.

Journal of Veterinary Internal Medicine

|March 16, 2017

Summary

Veterinary pathologists showed fair agreement on canine liver fibrosis scoring but poor agreement on necroinflammatory activity. This highlights variability in histological assessments, impacting clinical decisions and study designs for chronic hepatitis in dogs.

Keywords:

Chronic hepatitis Dog Hepatic fibrosis histological scoring

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Area of Science:

Veterinary Pathology
Histopathology
Canine Liver Disease

Background:

Histological grading schemes for hepatic fibrosis and necroinflammatory activity in humans have been applied to canine chronic hepatitis.
Interobserver agreement is crucial for reliable histological scoring systems.

Purpose of the Study:

To evaluate interobserver agreement among pathologists using a published scoring scheme for canine hepatic fibrosis and necroinflammatory activity.
To compare fibrosis scores from serial liver sections stained with hematoxylin & eosin (H&E) and picrosirius red.

Main Methods:

Six veterinary pathologists scored liver sections from 50 dogs with varying degrees of fibrosis and necroinflammation.
Multiuser kappa statistics assessed interobserver agreement.
Fibrosis scores from H&E and picrosirius red stained serial sections were compared using the Wilcoxon signed-rank test.

Main Results:

Multiuser kappa values for fibrosis and necroinflammatory activity were 0.35 and 0.16, respectively, indicating fair and poor agreement.
No significant difference was found in median fibrosis scores between H&E and picrosirius red stained serial sections (P = .248).

Conclusions:

Interobserver agreement for assessing canine liver fibrosis was fair, while agreement for necroinflammatory activity was poor.
This suboptimal agreement necessitates careful consideration by clinicians and researchers.
Recommendations include having multiple pathologists evaluate sections to reduce variability.