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Updated: Mar 6, 2026
Infant Auditory Processing and Event-related Brain Oscillations
Published on: July 1, 2015
Auditory impairment in infants with neonatal chronic lung disease is alleviated after term
1Division of Neonatology, Children's Hospital, Fudan University, Shanghai, China.
Insights
Infants with chronic lung disease (CLD) showed minor auditory impairment, with brainstem auditory evoked response (BAER) abnormalities improving after term age. These findings suggest early auditory issues in CLD infants may resolve over time.
Area of Science:
- Neonatal research
- Auditory neurophysiology
Background:
- Neonatal chronic lung disease (CLD) is associated with significant auditory impairment in term infants.
- Previous studies indicated major auditory deficits in very premature infants with CLD.
Purpose of the Study:
- To investigate auditory outcomes in infants with CLD at post-term age.
- To assess brainstem auditory evoked response (BAER) in CLD infants compared to controls.
Main Methods:
- Brainstem auditory evoked response (BAER) was recorded in 30 infants with CLD and 46 controls.
- Participants were assessed at a postconceptional age of 46-61 weeks.
- Data collected from cohorts in China and the UK.
Main Results:
- CLD infants exhibited slightly higher BAER thresholds.
- Minor alterations in BAER wave intervals (I-III shortening, III-V lengthening) were observed in CLD infants.
- BAER wave amplitudes were slightly smaller in CLD infants compared to controls.
Conclusions:
- Minor BAER abnormalities suggest subtle auditory impairment in CLD infants.
- Auditory impairment initially detected at term age showed signs of alleviation.
- Longitudinal auditory assessment is crucial for infants with neonatal chronic lung disease.
Aim:
Very premature infants with neonatal chronic lung disease (CLD) have been reported to have major auditory impairment at term, and we examined the outcomes in 30 infants after term age.
Methods:
Brainstem auditory evoked response (BAER) was recorded at a postconceptional age of 46-61 weeks in 13 CLD cases and 14 controls from China and 17 CLD cases and 22 controls from the UK.
Results:
The BAER threshold in the CLD infants was slightly higher. Clicks at the normal hearing level (60 dB) showed no significant differences between the cases and controls in the latencies of BAER waves I, III and V and the I-V interval. However, the CLD infants demonstrated marginal shortening in the I-III interval and a marginal increase in the III-V interval. The amplitudes of BAER waves in the CLD infants were all slightly smaller than the controls. At 70 and 40 dB normal hearing level, the BAER findings were similar to those obtained at 60 dB normal hearing level, with only small variations.
Conclusion:
There were minor BAER abnormalities in the CLD infants, suggesting minor auditory impairment. The auditory impairment previously detected at the term date was later alleviated.
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