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Pre-Procedural Guidelines for Assessing Blood Pressure01:10

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Accurate blood pressure assessment is crucial for diagnosing and managing various health conditions. To ensure the reliability of these measurements, healthcare professionals must adhere to standardized pre-procedural guidelines. These guidelines enhance patient safety and improve the overall quality of healthcare. The following steps are essential for obtaining accurate and consistent blood pressure readings, from using the appropriate tools to ensuring effective communication with the...
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Protocol for the prospective validation study: 'Screening programme for pre-eclampsia' (SPREE).

M Y Tan1, L Koutoulas1, D Wright2

  • 1Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
|March 16, 2017
PubMed
Summary
This summary is machine-generated.

This study evaluates a new Bayes

Keywords:
Bayes' theoremNational Institute for Health and Care Excellencefirst-trimester screeningmean arterial pressureplacental growth factorpre-eclampsiapregnancy-associated plasma protein-Auterine artery Doppler

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Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Clinical Trial Methodology

Background:

  • Pre-eclampsia (PE) is a significant cause of maternal and perinatal complications, affecting approximately 2% of pregnancies.
  • Current screening methods for PE, based on maternal demographics and history, have poor performance, identifying only about 35% of cases.
  • Early detection of PE is crucial for timely intervention and improved pregnancy outcomes.

Purpose of the Study:

  • To evaluate the effectiveness of a novel Bayes' theorem-based method for early prediction of pre-eclampsia.
  • To compare the performance of the 'combined test' and 'mini combined test' against current NICE guidelines.
  • To assess the utility of maternal characteristics, mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI), placental growth factor (PlGF), and pregnancy-associated plasma protein-A (PAPP-A) in PE screening.

Main Methods:

  • Prospective multicenter cohort study (SPREE study) involving pregnant women at 11-13 weeks' gestation.
  • Standardized recording of maternal characteristics, medical history, MAP, UtA-PI, PAPP-A, and PlGF.
  • Calculation of patient-specific PE risk using a Bayes' theorem-based approach.

Main Results:

  • The study hypothesizes that the first-trimester combined test and mini combined test will be superior to the current NICE screening method.
  • Data on pregnancy outcomes will be collected to validate the predictive performance of the novel screening methods.

Conclusions:

  • The SPREE study aims to establish a more accurate and effective screening program for pre-eclampsia.
  • Improved early detection of PE through advanced screening methods is expected to enhance maternal and perinatal health outcomes.